![]() The pharmacokinetic profile for the combination of afoxolaner and milbemycin oxime supports the rapid onset and a sustained efficacy for afoxolaner against ectoparasites and the known endoparasitic activity of milbemycin oxime. ![]() For the prevention of heartworm disease one month (30 days) after infection. The Cls was 5.0 ± 1.2, 75 ± 22 and 41 ± 12 mL/h/kg for afoxolaner, milbemycin oxime A3 and milbemycin oxime A4, respectively. It comes in a tasty chewable tablet that you should feed to your dog once a month. The V d was 2.6 ± 0.6, 2.7 ± 0.4 and 2.6 ± 0.6 L/kg for afoxolaner, milbemycin oxime A3 and milbemycin oxime A4, respectively. The volume of distribution (V d ) and systemic clearance (Cls) were determined following an IV dose of afoxolaner or milbemycin oxime. How Nexgard Chewable Works NexGard Dosage for Dogs For Small Dogs:Give one chew of NexGard (Orange Pack) to extra small dogs weighing between 4-10 lbs each. The terminal plasma half-life (t 1/2 ) and the oral bioavailability were 14 ± 3 days and 88.3% for afoxolaner, 1.6 ± 0.4 days and 80.5% for milbemycin oxime A3 and 3.3 ± 1.4 days and 65.1% for milbemycin oxime A4. ![]() The time to maximum afoxolaner plasma concentrations (t max ) was 2-4 h. This chewable is beef flavored and kills fleas, ticks, intestinal worms, and heartworms. Absorption of actives was rapid at levels that provide the minimum effective doses of 2.5 mg/kg and 0.5 mg/kg of afoxolaner and milbemycin oxime, respectively. One of the most popular chewable flea and tick controls for dogs is Nexgard Spectra. The pharmacokinetics of afoxolaner and milbemycin oxime (A3 and A4 forms) in dogs were evaluated following the oral administration of NexGard Spectra ® (Merial), a fixed combination chewable formulation of these two active pharmaceutical ingredients.
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